Associate Director/Director, DMPK

Boston, San Diego, Full Time

Rapport Therapeutics, a well-funded Third Rock start-up is seeking a talented drug metabolism and pharmacokinetic (DMPK) scientist responsible for leading the DMPK activities on multiple drug discovery programs targeting CNS therapeutics.

The successful candidate will be able to demonstrate the deep knowledge and experience in DMPK required to develop innovative therapeutics for patients living with serious neurological and neurodegenerative diseases. The candidate will preferably be based in San Diego, however candidates from San Francisco or Boston will be considered. Title and compensation will be commensurate with experience.

Key Responsibilities

  • Partner with project team members across multiple projects to drive and establish strategies for lead optimization, compound progression and candidate selection
  • Identify and understand the pharmacokinetics (PK) and absorption, metabolism, distribution, excretion (ADME) characteristics of lead compounds
  • Identifying ADME liabilities for a given scaffold and establish critical path assays to facilitate compound progression in medicinal chemistry
  • Design appropriate in vitro and/or in vivo assays to establish IVIVC and PK/PD relationships to enable human dose predictions
  • Derive human dose predictions that will inform candidate selection
  • Clear communication and interpretation of results to project and leadership teams
  • Establish external preclinical DMPK studies at CROs


  • Advanced degree in biochemistry, drug metabolism, pharmacokinetics or a related discipline and a Ph.D. with a minimum of 5 years experience in the biopharmaceutical industry or a M.S. with a minimum of 8 years experience in the biopharmaceutical industry is required
  • A proven track record in DMPK, which includes experiences in identifying, conducting and interpreting critical path ADME experiments needed to identify development candidates is required
  • Demonstration of the ability to design the experiments needed to establish PK/PD relationships is required
  • Experience conducting, interpreting and communicating the results of hands-on experiments and/or those of outsourced ADME assays are essential
  • Experience as DMPK lead on a CNS drug discovery program is preferred
  • An understanding of CNS drug disposition and transport across the blood-brain barrier is required
  • Experience with LC/MS/MS method development is desirable
  • Experience writing study reports, contributing to IND, IB and other regulatory documents is desirable
  • Excellent communication, collaboration, interpersonal, scientific thinking and problem-solving skills are required
Job Type: Full Time
Job Location: East Coast West Coast
Job City: Boston San Diego

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