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Scientific and Medical Meetings

American Epilepsy Society (AES) Annual Meeting, December 5-9, 2025

Efficacy and Tolerability of RAP-219, a Potential First-in-Class Negative Allosteric Modulator of γ8 Transmembrane AMPA Receptor Regulatory Protein (TARPγ8): Impact on RNS Long Episodes and Focal Seizures

William W. Motley, MD, D.Phil; Imran H. Quraishi, MD, PhD; Neal Nolan, MD; Daniel Friedman, MD; Patrick Landazuri, MD; Vikram…

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RAP-219: A Differentiated ASM Targeting Restricted Brain Expression of γ8 Transmembrane AMPA Receptor Regulatory Protein (TARPγ8)

Stephen Greene, PharmD; Marie Cohilis, PhD; Michel Koole, PhD; Kim Serdons, PhD; Marissa Herbots, MSN; Kathleen Sierens, MD; Jan de…

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Effect of RAP-219 on Long Episodes and Clinical Seizures in Adults With Drug-Resistant Focal Seizures and an Implanted Responsive Neurostimulator (RNS) System by Baseline Disease Severity: A Post-Hoc Analysis of a Phase 2a Proof-of-Concept Study

Neal M. Nolan, MD; Daniel Friedman, MD; William W. Motley, MD; Michael Gelfand, MD, PhD; Jeff Sevigny, MD; Patrick Landazuri,…

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Effect of RAP-219 on Seizure Severity in Adults with Drug-Resistant Focal Onset Seizures and an Implanted Responsive Neurostimulator (RNS) System: Analysis of a Phase 2a Proof-of-Concept Study

Arnold R. Gammaitoni, PharmD; Jacqueline A. French, MD; Neal M. Nolan, MD; Allison Little, PharmD; Taneeta M. Ganguly, MD; Shiling…

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Safety, Tolerability, and Pharmacokinetics of RAP-219 in Healthy Volunteers

Swamy Yeleswaram, PhD; Bradley S. Galer, MD; William W. Motley, MD; Stephen Greene, PharmD

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Novel Design of a Focal Epilepsy Proof-of-Concept Study of RAP-219, a Negative Allosteric Modulator of the γ8 Transmembrane AMPA Receptor-Associated Regulatory Protein (TARPγ8)

William W. Motley, MD; Daniel Friedman, MD; Kathryn A. Davis, MD; Bradley S. Galer, MD; Nancy Wyant, BA; Jose A….

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Optimal Cut Point for Reduction in Long Episode Frequency to Predict Meaningful Change in Clinical Seizure Frequency

Arnold R. Gammaitoni, PharmD; Martha J. Morrell, MD; Jacqueline A. French, MD; Daniel Friedman, MD; Kathryn A. Davis, MD; Thomas…

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Evolution of RAP-219 for the Treatment of Epilepsy
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American Academy of Neurology (AAN) Annual Meeting, April 5-9, 2025

American Epilepsy Society (AES) Annual Meeting – December 6-10, 2024

Optimal Cut Point for Reduction in Long Episode Frequency to Predict Meaningful Change in Clinical Seizure Frequency

Arnold R Gammaitoni, PharmD; Martha J. Morrell, MD; Jacqueline A French, MD; Daniel Friedman, MD; Kathryn A Davis, MD; Thomas K Tcheng, PhD; Cairn Seale, MS; Bradley S Galer, MD; William W Motley, MD

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Safety, Tolerability, and Pharmacokinetics of RAP-219 in Healthy Volunteers

Swamy Yeleswaram, PhD; Bradley S Galer, MD; William W Motley, MD; Stephen Greene, PharmD

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Impact of Food on the PK and Tolerability of RAP-219 in Healthy Volunteers

Stephen Greene, PharmD; Swamy Yeleswaram, PhD

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Antiseizure Effects with Selective TARPγ8 Negative Allosteric Modulators in Preclinical Seizure Models

Jose A. Matta, PhD; Brock Shireman, PhD; Laurie Volak, PhD; Michael P. Maher, PhD; David Bredt, MD, PhD

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Novel Design of a Focal Epilepsy Proof-of-Concept Study of RAP-219, a Negative Allosteric Modulator of the γ8 Transmembrane AMPA Receptor-Associated Regulatory Protein (TARPγ8)

William W Motley, MD; Daniel Friedman, MD; Kathryn A Davis, MD; Bradley S Galer, MD; Nancy Wyant, BA; Jose A Matta, PhD; Arnold R Gammaitoni, PharmD; Dennis Dlugos, MD, MSCE; Martha Morrell, MD; Jacqueline A French, MD

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Evolution of RAP-219 for the Treatment of Epilepsy
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Epilepsy Foundation Pipeline Conference, September 25-26, 2024

15th European Epilepsy Congress (EEC) 2024 – September 7-11, 2024

International Association for the Study of Pain (IASP) 2024 World Congress on Pain – August 5-9, 2024